Biology is an informational science that critically depends on accurate measurements and standards. Whether quantifying the amount of protein in a cancer cell or how well an organism converts sugar to alcohol, measurements are the foundation for improving our understanding of biological systems to meet the next generation of health care needs. What’s next depends on our ability to measure key features— including the complex interplay of thousands of biochemicals that control living systems. CSTL activities are focused to meet these challenges by advancing protein measurements, bioimaging, DNA diagnostics, and health care measurements.
26plex Autosomal STR Assay
3D Molecular Bioimaging Mass Spectrometry
Automated Live Cell Imaging for Quantification of Catalytic Rates in Individual Cells
Biocompatibility of Photoluminescent Silicon Nanoparticles
Bioscience and Health
Bioscience and Health
CCQM BAWG - P113
Cell-based Assay for Mechanistically-based Prediction of Cytoxicity
Cell-based Immunofluorescence Assays
Characterization of Dolphin Lung Endothelial Cells Through Quantitative Imaging
Chemical Characterization of Nanomaterial Formulations for Cancer Treatment in Support of the
NCI Nanotechnology Characterization Laboratory
Chromatographic Separation of Unfolded Proteins for Protein Quantification
Creatinine Methods and Measurements
Cytomegalovirus SRM
DNA Biometrics
DNA Mixture Interpretation
Decontamination of Biological Threats in Water Supplies
Depth Profiling of Drug Eluting Stent Coatings with Cluster SIMS
Development of Biomarker-based Systems for Cancer Detection and Therapy
Development of Enhanced mRNA Amplification using Microfluidics
Development of Methods for Measurement of Vitamin D in Foods, Fortified Foods, and Dietary Supplements
Development of Proteomics-Based Methods for Protein Quantification
Development of Reference Methods and Reference Materials for Proteins
Development of Reference Methods and Reference Materials for the Determination of Cardiac
Troponin I in Human Serum
Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum
Development of SRM 2669 for Accurate Assessment of Arsenic Exposure
Development of SRM 955c Lead in Caprine Blood
Development of SRMs for Accurate Assessment of Exposure to Toxic Elements and Anions
Development of SRMs for Serum Proteomics
Development of Serum-Based SRMs to Assess Nutritional Status
Development of Standard Reference Materials for Vitamins B6 and B12 in Human Serum
Development of a Collagen Fibril Reference Material for Reproducible Cell Response
Development of a Reference Measurement Procedure for C-Reactive Protein in Human Serum
Development of a Standard Reference Material for Metabolites in Plasma
Development of a Standard Reference Material for Vitamin D in Human Serum
Development of an Amino Acid (in Solution) Standard Reference Material
Environmental Leaching of Nanoparticles from Consumer Products
Expression of Stable Isotopically Labeled Proteins for Use as Internal Standards for Mass Spectrometric Quantitation of Clinical Protein Biomarkers
Fatty Acid Methods and Measurements
Fundamental Interaction Mechanisms of Engineered Nanomaterials with DNA
High-Precision Isotopic Reference Materials
Improved Benchtop Connectivity to Complex Microfluidic Devices
Improving Measurement Quality in Clinical Proteomics
Integrating Nanochannels with Microchannels
Measurement and Standards for Biotech Crop Detection and Quantification
Measurement and Standards to Support Nutrition Labeling
Measurements and Standards for Contaminants in Biological (Human) Materials
Measurements and Standards for Contaminants in Biological (Human) Materials
Measurements and Standards for Contaminants in Biological (Human) Materials
Metallomics: A Multidisciplinary Approach for the Qualitative and Quantitative Determination of Proteins and Metalloproteins Used as Health and Disease Markers
Metrologies for Protein Structure, Function, and Modeling
Microfluidic Synthesis of Nanoparticles
Micronutrients Measurement Quality Assurance Program
Multiparametric Measurement and Analysis of Cell Behavior on Extracellular Matrices
Nanoparticle Characterization
New Scalable Green Protocols for Processing Carbon Nanotubes
Next-Generation Metrology for Drug Delivery Systems
Ontologies and Interoperability in Evolutionary Comparative Analysis
Peptide Mass Spectral Libraries
Performance Metrics for Proteomics
Potential Primary Measurement Tool for the Quantification of DNA
Quantification of Cells with Specific Phenotypic Characteristics
Rapid Measurement of Aggregation of Protein Therapeutics During Biomanufacturing
Rapid Multiplex PCR
Renewal of NIST Benchmark SRMs for Accurate Determinations of Trace Elements in Serum and Liver Tissues
SRMs for Organic Contaminants in Human Serum, Milk, and Urine
Site Specific Bioimaging
Structural Databases
Superresolving Optical Microscopy
Surface Characterization of Conjugated Gold Nanoparticles
Surface Plasmon Resonance Imaging of Cells and Extracellular Matrix Proteins
Thermodynamics of Enzyme-catalyzed Reactions
Thermophysical Properties of Biofuels
Trophic Transfer of Nanoparticles in a Simplified Invertebrate Food Web
Understanding Protein Solution Phase Behavior via Coarse-Grained Modeling
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